中国汉族人群2型糖尿病易感性相关基因多态性

摘要

2型糖尿病(type 2 diabetes mellitus,T2DM)的发病与多个基因累加效应及多种环境因素相关.已在中国汉族人群中研究过的与T2DM易感性相关的基因多态性包括:全基因组相关研究中的CDKAL1、CDKN2A/B、SLC30A8、IGF2BP2、HHEX、FTO 以及KCNQ1基因;脂联素基因;核呼吸因子基因;葡萄糖激酶基因;肿瘤坏死因子α基因等.探索这些易感基因可以为人类治疗T2DM起到极大的推动作用.但至今已明确的基因依然很少,国内外的研究结果不尽相同,尚需进一步地深入研究.%Type 2 diabetes mellitus(T2DM)is determined by multiple gene additive effects and various environmental factors. The single-nucleotide polymorphisms(SNPs)related to T2DM candidate genes in the examined Chinese population include the genome-wide associated CDKAL1,CDKN2A/B,SLC30A8,IGF2BP2,HHEX,FTO and KCNQ1 genes,the adiponectin gene,the nuclear respiratory factor 1 gene,the glucokinase gene,and the tumor necrosis factor gene,etc. It is of great importance of exploring these susceptible genes to understand T2DM pathogenesis and improve T2DM treatment. However,few genes have been determined,due to divisive results. Therefore,further investigation needs to be undertaken.