Objective : To investigate the effcct of different echo times and ages on common metabolite content in the skeletal muscle of healthy volunteers in order to provide normal reference data set for the research of lesions occurred in or involved skeletal muscle by this method. Methods: 1 H-MRS data colleciion was done in soleus of calf with single voxel 1 H MRS protocol in 38 healrhy adulr volunteers. The type. content and relative content of common metabolites at echo time 30ms. 135 ms and 270 ms were compared. Results: Within three data set of 1 H-MRS of different echo time ( TE) in the soleus muscle of 38 adult volunteers. the intergral values of Cho. Cr. Lip. Lip2, Cho/Cr, Lip/Cr. Lip2/Cr were calculated.Peak areas rose with age in 30 ms of TE. The contents of Lip. Lip/Cr was significantly different among different age groups ( P ＜0, 05). Peak area increased with age in 135ms of TE too. The contents of Cho, Cr, Lip, Lip2 . Lip/Cr, Lip/Cr were significantly different among different age groups ( P ＜0. 05). In MRS with TE of 270 ms,spectral shape was unstable . and metabolite integrals showed poor. which was not included in the statistical analysis. Conclusion : With different echo times and ages, appearance of 1 H-MRS spectrum and contents of common metabolites are different in normal soleus muscle. This study of 1 H-MRS provide a basic dataset and new tool_for the research of lesions occurred in or involved skeletal muscle.%目的:探讨不同回波时间(TE)及年龄增长对正常成年人肌肉组织代谢物含量的影响,为用该方法研究发生于或累及骨骼肌的病变提供正常参考数据.方法:对38例健康成年志愿者小腿比且鱼肌行单体素1H-MRS检查,TE分别为30ms、135 ms和270ms,分析常见代谢物的种类、含量及相对含量.结果:在回波时间(TE)不同的三组1H-MRS数据中,38例志愿者均获得比目鱼肌内Cho、Cr、Lip、Lip2、Cho/Cr、Lip/Cr、Lip2/Cr的波谱下面积积分值,TE=30ms时,Lip 峰下面积随年龄增长而增加,不同年龄组间Lip、Lip/Cr含量差异具有统计学意义(P＜0.05);TE=135ms时,Lip峰下面积随年龄增长而增加,不同年龄组间Cho、Cr、Lip、Lip2、IAp/Cr、Lip/Cr含量差异具有统计学意义(P＜0.05);TE=270ms时MRS波谱形态不稳定,各物质的显示欠佳,未列入统计分析.结论:不同年龄及回波时间时,正常人比目鱼肌内1H-MRS谱线形态及常见代谢物的含量不同,为用1H-MRS研究骨骼肌病变以及其它可使骨骼肌受累的病变提供了基础数据和新的研究手段.
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