Objective:To investigate the pathology of multiple organ dysfunction syndrome caused by se-vere organophosphorus poisoning and treatment methods.Methods:A total of 52 patients with MODS were taken into this research.And they were divided into OBG (25 patients)and COG(25 patients)Group according to random number table.the OBG were treated with chrysophanol and the COG were treated with mannitol. Patients'pathological data of the two groups were collected and,the effectiveness of each method was ana lyzed.Results:In OBG ,the value of cholinesterase contained in serum was (0.5 ±0.20)kU/L,1 case was with intermediate syndrome,which accounted for 3.85% of all,2 cases died,which accounted for 7.698% of all,the length of stays was (10.21±3.5),symptom disappearing case was 24 and took up 92.31% of all;In the COG Group,the value of cholinesterase in serum was(0.4 ±0.09 )kU/L,3 patients were with intermediate syndrome,which took up 1 1.54%,5 patients died,which accounted for 1 9.23%,the length of stays was (17.82±5.3),symptoms of 21 cases disappeared,wich took up 80.77%,the differences between the 2 groups were obvious and statistically significant P <0.05.Conclusion:Respiratory tract,gastrointestinal tract clean-ing in early stage is the basis of treatment,and pay close attention to the functional status of patients'organs and make pre-monitoring so as to protect mucosa of gastrointestinal tract ,and positively give out treatment according to the characteristics of clinical symptoms ,so as to reduce the number of organs involved,and continuously improve the success rate of treatment.%目的：：探讨重度有机磷中毒致多器官功能障碍的病理以及诊治手段。方法：将某院收治的52例 MODS 患者作为观察对象,OBG 组患者给予大黄酚治疗,COG 组患者给予甘露醇治疗,统计病理数据,评价不同治疗方法治疗的有效性。结果：OBG 组治疗后血清胆碱酯酶值为(0.5±0.20)kU/L,中间综合症有1例,占比3.85%,死亡2例,占比7.69%,住院天数为(10.21±3.5)d,症状消失有24例,占比92.31%；COG 组患者治疗后血清胆碱酯酶值为(0.4±0.09)kU/L,中间综合症有3例,占比11.54%,死亡5例,占比19.23%,住院天数为(17.82±5.3)d,症状消失有21例,占比80.77%,组间比较具有显著差异和统计学意义,P <0.05。结论：早期的呼吸道、胃肠道清理是治疗的基础,并密切关注对患者的器官功能状态的预先监测,保护胃肠道黏膜,根据临床症状的特点积极治疗,从而降低器官累及数目,不断提高患者的救治成功率。
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