Objective To evaluate the application of measurement of T2*value,width of substantia nigra pars compacta (SNc) and the ratio of the width to the midbrain diameter in diagnosing Parkinson disease (PD) in early stage with susceptibility weighted imaging ( SWI) by 3T MR. Methods 59 patients with early stage idiopathic PD patients and 59 healthy controls,ranging in same ages and gender,had been scanned with routine sequences and SWI sequences by 3T MR. T2*value,width and the ratio of the width to the midbrain diameter of SNc were measured. The results of measurement were analyzed and compared. Results (1) The T2*values, width and the ratio of the width to the midbrain diameter was decreased in homolateral side SNc of symptoms of subjects with PD compared with the healthy controls ( <0.05) . (2) There was a significant reduction in the T2*values and the ratio of the width to the midbrain diameter in contralateral side SNc symptoms of subjects with PD compared with the healthy controls (P<0.05) . There was no differences in width of SNc ( >0.05) . Conclusion Measurement of T2*value, width and the ratio of the width to the midbrain diameter of SNc with SWI is reliable to diagnose PD.%目的：应用3.0 T磁共振磁敏感加权成像技术T2*图，探讨其在早期帕金森病（PD）研究中的价值．方法采用3.0T磁共振成像系统对59例原发性早期帕金森患者组及59名年龄、性别相匹配的正常对照组进行常规序列及SWI序列的扫描．经后处理在T2*图上分别手动测量双侧SNc宽度、中脑直径的比值（SNc宽度/中脑直径）、SNc的T2*值，并对测量结果进行对比分析．结果（1） PD症状同侧与正常对照组在SNc宽度、SNc宽度与中脑直径比值、T2*值有统计学意义（＜0.05）；（2） PD症状对侧与正常对照组在SNc宽度与中脑直径比值及T2*值有统计学意义（＜0.05），而在SNc宽度差异无统计学意义（＞0.05）．结论采用SWI测量SNc的T2*值、宽度以及宽度与中脑直径比值对诊断PD具有一定的临床价值．
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