胆甾醇辛酸酯-辛酰基-1-13C的合成

摘要

采用缩合与催化的组合方式,利用胆固醇(Ch-OH)与辛酸-1-13C反应,合成胆甾醇辛酸酯-辛酰基-1-113C(ChO-13 C),产率84.1％,13C丰度99.0％,光学纯度99.0％,化学纯度99.5％.用HPLC-ELSD、LC-MS和1 H NMR对产品进行表征,确定产品为胆甾醇辛酸酯结构.%Cholesteryl octanoate-octanoyl-l-13C was synthesized by a method of coupling-catalysis. The yield of 13C labeled Cholesteryl octanoate was 84. 1% (based on Cholesterol) , with 99. 0% atom 13C 99. 0% optical purity and 99. 5% chemical purity. The product was characterized by HPLC-ELSD, LC-MS and 1H NMR. The structure and 13C isotopic enrichment of it was determined and measured by LC-MS and 1H NMR.