肝细胞癌患者TACE后外周血调节性T细胞水平对预后的影响

摘要

目的 探讨肝细胞癌(HCC)患者TACE治疗后外周血调节性T细胞(Treg)水平与预后的关系.方法 回顾性分析天津医科大学附属肿瘤医院收治的122例HCC患者经TACE治疗后外周血中Treg占CD4+T细胞比例与生存时间(OS)的关联.结果 HCC患者TACE后Treg细胞占CD4+T细胞的比率显著升高(分别为6.109和6.834,P=0.000);低Treg组(＜6.7)HCC患者中位生存期19.3个月,高Treg组(≥6.7)中位生存期12个月,两组间OS存在显著差异.结论 HCC患者TACE治疗后外周血Treg水平是判断预后的独立预测指标.%Objective To discuss the correlation between regulatory T cells (Treg) level in peripheral blood and the prognosis in patients with hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE). Methods A total of 122 patients with HCC who received TACE at authors' hospital were enrolled in this study. The CD3+ T, CD4+ T, CD8+ T, NK and Treg levels in peripheral blood were assessed by flow cytometry method. The relationship between the Treg level in peripheral blood and the survival time was evaluated by Cox regression and Kaplan - Meier analysis. Results In HCC patients after TACE, the ratio of Treg cells to CD4+ T was significantly increased (6.109 and 6.834,P = 0.000). In lower ratio group(ratio of Treg cells to CD4+ T ＜ 6.7), the median survival time of patients was 19.3 months, while in higher ratio group (ratio of Treg cells to CD4+ T ≥ 6.7), the median survival time of patients was 12.0 months. The difference between the two groups was statistically significant by using single factor analysis (x2 = 8.771 ,P = 0.003) or multivariate analysis(P = 0.020). Conclusion The Treg level in peripheral blood is an independent predictive factor for judging the prognosis of HCC patients after TACE.