超声造影引导下微波消融联合TACE治疗肝转移瘤

摘要

Objective To evaluate the clinical efficacy of percutaneous microwave coagulation therapy (PMCT) under contrast - enhanced grey - scale ultrasonography (CEUS) guidance combined with transcatheter arterial chemoembolization (TACE) in treating hepatic metastatic carcinomas. Methods Fifty patients with clinically conformed hepatic metastatic carcinomas were randomly and equally divided into two groups; the combination group and the control group. Patients in the combination group (re = 25) received TACE together with PMCT treatment, while patients in the control group (re = 25) were treated with TACE alone. The therapeutic results were analyzed and compared between the two groups. Results In the combination group, complete remission (CR) was seen in 7 cases, partial remission (PR) in 15 cases, stable disease (SD) in 2 cases and progressive disease (PD) in one case, with a remission rate of 88%. In the control group, CR was seen in 3 cases, PR in 11 cases, SD in 6 cases and PD in 5 cases, with a remission rate of 56%. The difference in the remission rate between the two groups was statistically significant (P ＜ 0.05). In the combination group, the levels of T cell subsets (CD3, CD4, CD16CD56 and CD3CD56) determined after the treatment were significantly higher than those determined before the treatment (P ＜ 0.05). Conclusion For the treatment of hepatic metastatic carcinomas, CEUS-guided PMCT combined with TACE is superior to pure TACE. The clinical efficacy can be significantly improved.%目的 探讨超声造影引导下微波消融联合经导管肝动脉化疗栓塞术(TACE)在治疗肝转移瘤的价值与疗效.方法 转移性肝癌患者50例,单纯TACE组25例,微波消融联合TACE组25例,分析两组疗效.结果 单纯TACE组CR 3例,PR 11例,SD 6例,PD 5例,缓解率为56％; TACE联合经皮微波凝固治疗(PMCT)联合组CR 7例,PR 15例,SD 2例,PD 1例,缓解率88％,两组缓解率比较差异有统计学意义(P＜0.05).联合组治疗后CD3、CD4、CD16CD56、CD3CD56水平明显高于治疗前(P＜0.05).结论 超声引导下PMCT联合TACE治疗肝转移瘤能提高疗效.