经皮旋切术结合臭氧注射对腰椎间盘突出症患者血清前列腺素E1α和脑钠肽的影响

摘要

目的 观察经皮旋切术结合臭氧注射治疗对腰椎间盘突出症患者血清6-酮前列腺素E1α(6-keto-PGE1α)和M-脑钠肽(M-ENK)含量的影响.方法 90例腰椎间盘突出症患者按入组先后随机数字表法分为经皮旋切术联合臭氧组(A组)、臭氧治疗组(B组)和旋切治疗组(C组),每组30例.分别于治疗前后测定3组患者血清中6-keto-PGE1α和M-ENK的含量.结果 3组患者血清中6-keto-PGE1α含量在治疗后均呈下降趋势,而M-ENK的含量较治疗前均升高,与B组和C组比较,A组前后变化更显著(P ＜ 0.01);B、C两组间治疗前后比较亦有显著性差异(P ＜ 0.05).结论 经皮旋切术结合臭氧注射治疗对腰椎间盘突出症患者血清中6-keto-PGE1α和M-ENK含量有良性调节作用.这可能是此法治疗本病的作用机制之一.%Objective To investigate the influence of percutaneous atherectomy combined with ozone injection on the serum 6-keto-PGE1α and M-ENK levels in treating patients with lumbar disc protrusion. Methods Based on random number table method, a total of successive 90 patients with lumbar disc protrusion were randomly divided into group A (n = 30, percutaneous atherectomy plus ozone injection), group B (n = 30, ozone injection) and group C (n = 30, percutaneous atherectomy). The serum 6-keto-PGE1α and M-ENK levels in all patients were determined before and after the treatment. Results After the treatment, the serum 6-keto-PGE 1α level showed a declining tendency, while the serum M-ENK level was elevated in all the three groups. The above changes in serum 6-keto-PGE 1α and M-ENK levels were more significant in group A than those in group B and group C (P < 0.01). Significant difference in serum 6-keto-PGE1α and M-ENK levels existed between group B and group C (P < 0.05). Conclusion In treating patients with lumbar disc protrusion, percutaneous atherectomy combined with ozone injection has benign regulation effect on the serum 6-keto-PGE1α and M-ENK levels, and this effect may be one of its therapeutic mechanisms for lumbar disc protrusion.