抗苗勒管激素和抑制素B预测卵巢反应性及ART结局的研究进展

摘要

女性生育力是人类繁衍的珍稀资源，卵巢储备是生育力的决定者和体现者；随着女性年龄增加，卵巢内卵子的数量和质量均呈下降趋势，是影响辅助生殖技术助孕成功率的主要因素。为了指导个体化用药，获得优质卵子，越来越多的临床指标用于预测卵巢储备，成为体外受精前常规检测指标。现对抗苗勒管激素（AMH）和抑制素B（INH B）在预测卵巢功能和ART结局方面的最新研究进展进行综述，认为AMH对卵巢低反应、高反应及卵巢过度刺激综合征（OHSS）均有良好的预测价值；INH B的预测价值并不优于其他指标；目前尚无预测辅助生殖技术妊娠结局的良好指标。%Female fecundity,which depends on the ovarian reserve,plays important role in human reproduction. The age-related poorer outcome of ART largely attributes to the declined oocyte quality and quantity. Some ovarian reserve tests (ORTs) and predictors have been applied in infertile patients undergoing IVF/ICSI treatment to explore individualized FSH dose regimens. Anti-Müllerian hormone (AMH) and inhibin B (INH B) could be considered as two markers of ovarian reserve and outcomes of ART. It was acceptable that AMH could be used to predict the poor ovarian response,excessive response and ovarian hyperstimulation syndrome,and that INH B was not better predictor than others. In fact,there was a very good predictor to predict accurately the pregnancy outcomes of ART.