胰岛素样生长因子家族在卵巢癌中的研究进展

摘要

胰岛素样生长因子(IGF)家族存在于正常卵巢中,在细胞的增殖、分化和凋亡中起重要作用.越来越多的研究发现,IGF家族参与包括卵巢癌在内的众多恶性肿瘤的发生和发展.近年来对卵巢癌细胞和组织中IGF家族开展的大量研究结果显示,IGF家族可能在卵巢癌的转化和恶性进展中起重要作用,抑制其受体信号通路可能为卵巢癌的综合治疗提供新靶点.就IGF家族在卵巢癌领域的最新研究进展进行综述.%Insulin-like growth factors (IGF) plays a pivotal role in human ovarian cell proliferation,differentiation and apoptosis. Increasing evidences have revealed that IGF system is involved in the pathogenesis and progress of various malignancies including ovarian cancer. Recent studies in regard to IGF axis expression in the ovarian cell lines and tissues have shown that the IGF axis may contribute to the transformation and progression of ovarian cancer. The inhibition of IGF receptor signaling pathway may be a new strategy for the multimodality treatment of ovarian cancer. This article reviews the update progress in the research of IGF axis in ovarian cancer.