Biological method is an ideal way to remove the toxin from contaminated feed compared with both physical and chemical methods. A new microbiological agent, BH was used to reduce the toxicity of mildewed wheat containing deoxynivalenol(DON) at 22. 7 mg per kg feed. Experimental animals included two batches of 24 pigs (5 kg ) and 48 pigs (30 kg). Each batch was randomly divided into 4 groups fed with diets supplemented with different agents as follows: Group 1, + DON; Group2, + DON+ BH; Group3, + BH ;Group4, just the routine diet as control. The pigs were weighed every 2 weeks, while blood biochemical items were detected every 3 weeks during the experimental period of 6 weeks. The results showed that DON significantly reduced the weight gain of both batches. BH greatly alleviated the harm of DON to the animals.However, BH alone had no influence on weight gain. Furthermore, DON increased some biochemical items significantly, such as AST and GPT. In vitro, BH reduced the amount of DON in liquid medium, while BH added mildew feed did not apparently affect the content of DON in feed if they did not pass the gastrointestine.
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