急性心肌梗塞溶栓治疗相关动脉再灌注对QT离散度的影响

摘要

目的 探讨急性心肌梗塞(AMI)患者溶栓治疗相关动脉再灌注对QT离散度(QTd)的影响。方法 62例AMI患者分为溶栓再通组、未通组及非溶栓组，测量溶栓前后QTd，并进行比较。结果 AMI溶栓前溶栓组（65.6±13.9)ms与非溶栓组（63.2±18.2)msQTd差异无显著性（P＞0.05），溶栓治疗再通后，QTd明显减小。溶栓未通组及非溶栓组（46．7±11．6)ms、(47．5±13.2)ms，显著高于溶栓再通组（31.4±9.4)ms，(P＜0.01）。伴心室颤动者QTd（70．6±16.2)ms明显高于不伴心室颤动者（47.9±13.5)ms，(P＜0.01）。结论 急性心肌梗塞溶栓治疗相关动脉再灌注后QTd明显减小，心室颤动的发生率降低。%Objective To study the effect of reperfusion of infarct-relatedartery after thrombolytic therapy on QT dispersion（QTd）in patients with acute myocardial infarction（AMI）．Methods 62 cases were divided into three groups：thrombolytic and recanalized group，uncanalized group and non-thrombolytic group．The QTd was measured before and after thrombolytic therapy and the results were compared．Results The QTd was not significant difference（P＞0．05）in patients with AMI before thrombolytic therapy between thrombolytic group [（65．5±13．9） ms] and non-thromblytic group[（63．2±18．2）ms]．The QTd decreased significantly in thrombolytic and recanalized group．The QTd [（46．7±11．6 ms、47．5±13．2）ms] in uncanalized group and non-thrombolytic group were all higher than that in thrombolytic and recanalized group [（31．4±9．4） ms]（P＜0．01）．The QTd of ventricular fibrillation （VF） group was greatly higher than those without VF[（70．6±16．2） ms，（47．9±13．5） ms]（P＜0．01）．Conclusion Reperfusion of infarct-related artery was associated with the reduction of QTd．and the lower incidence of VF．