肝病患者血清HA、PCⅢ水平在肝纤维化诊断中的意义

摘要

ObjectiveTo study serm hyoluronic Acid and Precollagen Level of hepatopath in diagnosis of hepatic fibrosis. Methods　Serum HA and PCⅢ in 316 patients with viral hepatitis B and cirrhosis of liver were measured by radioimmunoassay (RIA). Results　Except acute hepatitis group, the level of each group in hepatopath of serum HA and PCⅢ were higher than those of the control group, HA (P＜0.05),PCⅢ ( P＜0.01). The highest level of them was in cirrhosis of liver,the next was in chronic active hepatitis and severe hepatitis.The degree of relationship between the level of HA and PCⅢ and the level of fibroplastic proliferation in biopsy liver were analysed in 19 patients with cirrhosis of liver and chronic active hepatitis. Conclusion　There were significant correlations between them. So HA and PCⅢ can reflect the degree of fibroplastic proliferation in liver, and are a better serum diagnosis index of liver fibrosis.%目的探讨肝病患者血清HA、PCⅢ水平在肝纤维化诊断中的意义。方法采用放射免疫测定法测定了316例乙型肝炎及肝硬化患者血清透明质酸和Ⅲ型胶原水平。结果除急性肝炎组外，各组肝病患者HA、PCⅢ水平均高于对照组，HA(P＜0.05)，PCⅢ( P＜0.01) 。以肝硬化组升高最为明显，HA达629.56±293.98ng/ml PCⅢ达221.96±120.64ng/ml。其次为慢性活动性肝炎组及重症肝炎组。将19例肝硬化、慢活肝患者血清HA、PCⅢ水平与其肝活检组织纤维增生程度进行相关分析，发现两者相关显著(r＝0.75,P＜0.01)。结论 HA、PCⅢ能够较好地反映肝纤维增生情况，是一个较好的肝纤维化血清学诊断指标。