目的：探讨外科手术创口感染主要病原菌分布及其耐药性。方法采集外科手术伤口分泌物样本进行细菌培养和药敏试验，并对细菌培养和药敏结果进行分析。结果分泌物样本675份，样本病原菌检出率为79.1%，其中革兰阴性菌占62.0%；药敏结果显示革兰阳性菌对青霉素和大环内酯类抗生素耐药率最高，革兰阴性菌对青霉素敏感性最低，对万古霉素和碳氢霉烯类抗生素最敏感。结论外科创口术后感染主要以革兰阴性菌为主，对临床常规抗菌药物相对较为敏感，但对万古霉素和碳氢霉烯类抗生素最为敏感。%Objective The purpose of this study is trying to preliminary understanding the inflectional pathogen dis⁃tribution and drug-resistance in wound of surgical patient in Kunming Child Hospital in recent years, and providing the da⁃ta to develop prevention strategies and provide evidence to reasonably using the antibiotics. Methods Bacterial culture and sensitivity test were conducted using surgical patient wound swabs from September 2013 to September 2014. Results A total of 675 wound swabs were collected, and pathogen detection rate was 79.1%, the most of them was opportunistic pathogens and gram-negative bacteria accounted for 62.0%. The drug sensitivity results showed that the highest resistant drugs for gram-positive bacteria were penicillin and macrolide antibiotics, the lowest sensitive drug for gram-negative was penicillin, but the most sensitive drug for two kinds of bacteria was vancomycin and carbapenem antibiotics. Conclu⁃sions Gram-negative bacteria were the main pathogens in wound of surgical patients, and detected bacteria from collect⁃ed samples showed different sensitivity to clinical routine antimicrobial agents, but the most sensitive drugs are vancomy⁃cin and carbapenem antibiotics. However, it should strengthen the analysis of identification and sensitivity test for the in⁃fecting bacteria, and only rational using of antimicrobial drugs could achieve the best therapeutic effect.
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