目的 探讨胰岛素样生长因子-Ⅰ(insulin-like growth factor-Ⅰ,IGF-Ⅰ)、胰岛素样生长因子-Ⅱ(insulin-like growth factor-Ⅱ,IGF-Ⅱ)在胃癌中的表达及与胃癌浸润转移等生物学行为的关系.方法 对胃癌患者40例的癌组织、距原发灶5cm以上切缘组织和正常胃组织标本10例进行IGF-Ⅰ、IGF-Ⅱ免疫组织化学染色.结果 ①胃癌组织中IGF-Ⅰ的表达率显著高于切缘组织和对照组(P＜0.05);切缘组织和对照组中表达率差异无统计学意义(P＞0.05);病理分期中Ⅰ、Ⅱ期与Ⅲ、Ⅳ期比较差异有统计学意义(P＜0.05);无淋巴结转移组与淋巴结转移组相比差异有统计学意义(P＜0.05);未侵及全层组与侵及全层组相比差异有统计学意义(P＜0.05).②胃癌组织中IGF-Ⅱ的表达率显著高于切缘组织和对照组(P＜0.05).切缘组织和对照组中表达率差异无统计学意义(P＞0.05).病理分期中Ⅰ、Ⅱ期与Ⅲ、Ⅳ期比较差异有统计学意义(P＜0.05);无淋巴结转移组与淋巴结转移组相比差异有统计学意义(P＜0.05);未侵及全层组与侵及全层组相比差异有统计学意义(P＜0.05).结论 IGF-Ⅰ、IGF-Ⅱ的高表达与胃癌的发生有关,且均参与了胃癌的侵袭和转移.%Objective To investigate the relationship of the expression of insulin - like growth factor - I ( IGF - I ) and insulin - like growth factor - II ( IGF - II ) with the histological type, pathologic tumor - node - metastasis( PTNM ) stage, infiltration as well as metastasis of gastric carcinoma ( GC ). Methods The expression of IGF - I and IGF - II were tested by S - P immunohistochemistry in 40 cases of GC tissues, margin tissues which were more than 5 cm from primary focus in distance and 10 cases of normal gastric mucosa. Results ①The expression rate of IGF - I in GC group was much higher than in margin tissues and normal gastric mucosa groups( P < 0. 05 ). There was no significantrndifference between margin tissues group and normal gastric mucosa groups( P > 0. 05 ). The expression of IGF - I was closely correlated to the tumor PTNM stage, lymph node metastasis and depth of infiltration ( P <0. 05 ). ②The expression rate of IGF - II in GC group was much higher than in margin tissues and normal gastric mucosa groups( P < 0. 05 ). There was no significant difference between margin tissues group and normal gastric mucosa group( P > 0. 05 ). The expression of IGF - II was closely correlated to the tumor PTNM stage, lymph node metastasis and depth of infiltration( P < 0. 05 ). Conclusion The excessive expression of IGF - I and IGF - II is closely correlated to carcinogenesis of GC. It may be involved in the development,infiltration and metastasis of GC.
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