Objective: To explore the effect of tibolone as well as estradiol and drospirenone replacement therapy on the neurohumoral indexes and immune function in perimenopausal women.Methods: A total of 180 perimenopausal women who were treated in our hospital were collected and divided into the tibolone group (n=90) as well as estradiol and drospirenone group (n=90) by random number table.They received tibolone as well as estradiol and drospirenone replacement therapy respectively, and both therapies lasted for 6 months.The differences in serum levels of neurohumoral indexes and immune function indexes were compared between the two groups.Results: Before treatment, differences in serum levels of neurohumoral indexes and immune function indexes were not statistically significant between the two groups (P>0.05).After 6 months of treatment, serum E2, IL-4 and IL-13 levels of both groups of patients were significantly higher than those before treatment while P, T, FSH, LH, PRL, IFN-γ and IL-2 levels were significantly lower than those before treatment, and serum E2, IL-4 and IL-13 levels of observation group were significantly higher than those of control group while P, T, FSH, LH, PRL, IFN-γ and IL-2 levels were significantly lower than those of control group (P<0.05).Conclusions: Both tibolone and estradiol and drospirenone can be used in the treatment of women with perimenopausal syndrome, but tibolone is more effective in optimizing hormone levels and equalizing immune function.%目的:探讨替勃龙和雌二醇屈螺酮替代治疗对围绝经期女性的神经体液指标及免疫功能的影响.方法:收集在本院接受治疗的围绝经期女性180例,随机分为替勃龙组、雌二醇屈螺酮组各90例,分别接受替勃龙、雌二醇屈螺酮替代治疗,持续6个月.对比两组研究对象治疗前后血清中神经体液指标、免疫功能指标含量的差异.结果:治疗前,两组血清中神经体液指标、免疫指标水平的差异无统计学意义(P>0.05).治疗6月后,两组血清中E2、IL-4、IL-13的含量均较治疗前显著升高,P、T、FSH、LH、PRL、IFN-γ、IL-2的含量均较治疗前显著降低且观察组患者血清中E2、IL-4、IL-13的含量均较对照组患者显著升高,P、T、FSH、LH、PRL、IFN-γ、IL-2的含量均较对照组患者显著降低(P<0.05).结论:替勃龙、雌二醇屈螺酮均可用于女性围绝经期综合征的治疗,但替勃龙在优化激素水平、均衡免疫功能方面的作用更优.
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