Research progress of long non-coding RNA in dilated cardiomyopathy

摘要

Dilated cardiomyopathy(DCM)is a type of composite cardiomyopathy characterized by left ventricular,right ventricular or double ventricular enlargement and diastolic dysfunction caused by genetic and non-genetic causes,with a high incidence,High mortality,gradual rejuvenation,etc.,are common types of cardiomyopathy.With the progressive development of the disease,it can cause arrhythmia,severe heart failure,thromboembolism,and even sudden death.Currently,there is no effective treatment plan,and the high mortality rate is a major problem in the treatment of cardiovascular diseases.Long-chain non-coding RNAs(lncRNAs)are a class of RNAs with a molecular mass of more than 200 bt and which are not involved or rarely involved in protein coding.Studies have shown that lncRNAs play an important role in the occurrence and development of DCM.Finding relevant clinical diagnostic markers and therapeutic targets is the current research focus in the field of DCM.This article reviews the mechanism and research progress of lncRNAs in the occurrence and development of DCM,and aims to provide a new direction for the prevention and treatment of DCM.