Network pharmacological study on the annti-inflammatory mechanism of XuanBaiChengQi Decoction in the treatment of novel coronavirus pneumonia (COVID-19)

摘要

Objective:To clarify potential molecular mechanism of annti-inflammatory and signal pathways of XuanBaiChengQi(XBCQ)Decoction in treatment on COVID-19.Methods:The active ingredients and targets of XBCQ Decoction were searched from the TCMSP、literature and Swiss Target Prediction.COVID-19 pneumonia targets were obtained by the GeneCards.A protein-protein interaction(PPI)network was constructed through the STRING database.Metascape datebase was used to perform Gene Ontology(GO)function enrichment and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis.And then Cytoscape 3.7.2 software was used to create an active ingredients-target-disease network.Results:Apart from gypsum,XBCQ Decoction contains 3 herbs,52 compounds and 674 relavent targets.The targets of the main active ingredients of XBCQ Decoction were intersected with the therapeutic targets of the COVID-19 pneumonia,obtaining 78 key targets.Network of drug components-target-disease indicated that 5 compounds(e.g.α-Spinasterol、Chrysophanic acid、Palmidin A、Vitamin-e、Physcion)play crusial role in treatment.Conclusion:From these ways,we found some key molecular targets,such as CYP19A1,PTGS2,EGFR,BCL2,HMGCR,PPARG,NOS2,SLC6A4,MAPK1,MAPK3.These targets jointly participate in the regulation of Pathways in cancer,MAPK signal pathway,Jak-STAT signal pathway and many other signal pathways,among which anti-inflammatory effect may be the main mechanism of XuanBaiChengqi Decoction.