Correlation of the change of HIF-1α in oral squamous cell carcinoma lesion with lymph node metastasis and malignant biological molecule expression

摘要

Objective: To study the correlation of the change of hypoxia-induced factor-1α (HIF-1α) in oral squamous cell carcinoma lesion with lymph node metastasis and malignant biological molecule expression. Methods: The patients with oral squamous cell carcinoma who underwent surgical resection in the First Hospital of Yulin between March 2012 and December 2017 were selected as the research subjects, and right amount of oral squamous cell carcinoma lesion and lesion adjacent to carcinoma were collected after surgical resection to determine the mRNA expression of HIF-1α, proliferation genes and invasion genes as well as the contents of angiogenesis molecules. Results: HIF-1α, PCNA, CDK4, CDK6, Slug, β-catenin and MMP9 mRNA expression as well as VEGF, Ang-2, bFGF and COX-2 contents in oral squamous cell carcinoma lesions were significantly higher than those in adjacent lesions whereas PDCD5, Smac, E-cadherin and RECK mRNA expression were significantly lower than those in adjacent lesions; Pearson correlation analysis showed that HIF-1α mRNA expression in oral squamous cell carcinoma lesions was positively correlated with PCNA, CDK4, CDK6, Slug, β-catenin and MMP9 mRNA expression as well as VEGF, Ang-2, bFGF and COX-2 contents, and negatively correlated with PDCD5, Smac, E-cadherin and RECK mRNA expression. Conclusion: Highly expressed HIF-1α in oral squamous cell carcinoma can promote the proliferation and invasion of cancer cells as well as the angiogenesis in the lesion.