Effects of retroperitoneal laparoscopic radical nephrectomy on stress indexes, tumor markers and renal function in patients with renal cancer

摘要

Objective: To study the Laparoscopic kidney cancer after Radical prostatectomy, Laparoscopic Radical Nephrectomy, LRN) stress index, tumor markers, and renal function in patients with kidney cancer. Methods: A total of 80 patients with renal cancer treated in our hospital were randomly divided into control group and study group (40 patients in each group). The changes of stress index, tumor marker and renal function before and after operation were compared between the two groups. Results: After operation, stress index, tumor marker and other indicators in both groups were significantly reduced, while the levels of FT3 and FT4 in patients undergoing retroperitoneal laparoscopic radical nephrectomy were significantly lower than those in the control group. After laparoscopic radical resection, tumor inflammatory factors such as CA50, CEA and CA125, as well as inflammatory factors such as TNF-α, serum cortisol and c-reactive protein (CRP) were significantly reduced compared with the control group. Meanwhile, the decreased levels of blood urea nitrogen (BUN) and blood creatinine (SCr) in the study group were significantly higher than those in the control group, indicating that the recovery of renal function in the study group was better than that in the control group. Conclusions: Compared with open radical nephrectomy, retroperitoneal laparoscopic radical nephrectomy can effectively reduce the stress response, inflammatory factors, inflammatory reaction and tumor markers, and significantly improve the recovery of renal function.