Objective:To study the effect of octreotide combined with carthamin yellow on inflammatory cytokines, endocrine hormones and signaling molecules in patients with severe acute pancreatitis.Methods: The patients who were diagnosed with severe acute pancreatitis in our hospitals between June 2014 and October 2017 were selected and randomly divided into the experimental group who accepted octreotide combined with carthamin yellow + conventional symptomatic treatment and the control group who accepted octreotide + conventional symptomatic treatment. Before treatment as well as 5 d and 10 d after treatment, the contents of inflammatory cytokines and endocrine hormones in serum as well as the expression of signaling molecules in peripheral blood were measured.Results: At 5 d and 10 d after treatment, serum TNF-α, ICAM-1, MCP-1, IL-8, sTREM-1, COR, PCT, copeptin, AT-II and ghrelin contents as well as peripheral blood FasL, NOX2, TLR4, TLR9 and p38MAPK expression intensity of both groups were significantly lower than those before treatment, and serum TNF-α, ICAM-1, MCP-1, IL-8, sTREM-1, COR, PCT, copeptin, AT-II and ghrelin contents as well as peripheral blood FasL, NOX2, TLR4, TLR9 and p38MAPK expression intensity of experimental group at 5 d and 10 d after treatment were significantly lower than those of control group.Conclusion: Octreotide combined with carthamin yellow therapy for severe acute pancreatitis can significantly improve the inflammatory response activation and endocrine hormone disorder.
展开▼
