Effect of Bailing capsule combined with Edaravone on immune function, antioxidant function and related factors in patients with chronic obstructive pulmonary disease

摘要

Objective:To investigate the effects of Bailing capsule combined with edaravone on immune function, antioxidant function and related factors in patients with chronic obstructive pulmonary disease (COPD).Methods:160 patients with COPD who received treatment in the department of respiratory medicine of our hospital from March 2016 to March 2018 were randomly divided into control group and observation group, 80 cases in each group. Patients in the control group received edaravone treatment, while patients in the observation group received bailing capsule combined with edaravone treatment. The levels of T lymphocyte, superoxide dismutase (SOD), malondialdehyde (MDA), nitric oxide (NO), transforming growth factor-β1 (TGF-β1), tumor necrosis factor-α (TNF-α) and matrix metalloproteinase-9 (MMP-9) were measured and compared before and after treatment.Result: After treatment, the levels of CD3+, CD4+, CD4+ / CD8+, SOD and NO of patients in the control group and the observation group were significantly higher than those before treatment, while the levels of CD8+ and MDA were significantly lower than those before treatment. The change trend of the levels of T lymphocyte and antioxidant enzyme of patients in the observation group were significantly more obvious than that in the control group (P<0.05). After treatment, the serum levels of TGF-β1, TNF-α and MMP-9 of patients in the control group and the observation group decreased significantly, and the change trend of the above factors of patients in the observation group was more obvious than that in the control group (P<0.05).Conclusion: Bailing capsule combined with edaravone in the treatment of chronic obstructive pulmonary disease can significantly enhance the immune function and antioxidant function of patients and alleviate inflammation of the body. It has good clinical curative effect.