Objective:To observe the effect of 6% hydroxyethyl starch preloading 30 min before the epidural block anesthesia on hypotension and adverse reactions after anesthesia.Methods: A total of 80 patients undergoing abdominal surgery under an epidural block anesthesia were included in the study and randomized into the observation group and the control group. The patients in the two groups were given injections of 6% hydroxyethyl starch and sodium lactate ringer, respectively 30 min before anesthesia. The changes of SBP and HR before anesthesia (T0), 1 min (T1), 5 min (T2), 10 min (T3), 15 min (T4), and 20 min (T5) after anesthesia, and the occurrence of adverse reactions in the two groups were observed.Results: The comparison of SBP and HR at T0, T1, T2, and T5 between the two groups was not statistically significant (P>0.05). SBP at T3 and T4 in the observation group was significantly higher than that in the control group, while HR was significantly lower than that in the control group (P<0.05). The occurrence rates of hypotension, nausea and vomiting, and the utilization rate of ephedrine in the observation group were significantly lower than those in the control group (P<0.05).Conclusions: Venous preloading of 6% hydroxyethyl starch 30min before the epidural block anesthesia can effectively prevent the occurrence of hypotension during the anesthesia period, significantly reduce the occurrence of adverse reactions, and is favorable of a successful operation.
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