Analysis of quantitative EEG detection results of patients with Alzheimerˊs disease and its correlation with serum index

摘要

Objective: To study the quantitative EEG detection results of patients with Alzheimer's disease and its correlation with serum index. Methods: 50 patients with Alzheimer's disease diagnosed in our hospital from May 2012 to August 2014 were enrolled in the observation group; healthy people who received physical examination in our hospital during the same period were enrolled in the control group. Then quantitative EEG detection was conducted and serum was collected to detect contents of inflammatory factors and serum neuron injury related molecules. Results: (1)quantitative EEG: ( +θ)/( +β) ratios of whole brain, frontal lobe, temporal lobe, parietal lobe and occipital lobe of the observation group were higher than those of the control group; (2)inflammatory factors: serum TNF- , IL-1β, IL-6, MMP2, MMP9 and ET contents of the observation group were higher than those of the control group and were positively correlated with ( +θ)/( +β) ratios;(3) neuron injury related molecules: serum Hcy, Aβ1-42, Tau, Glu, Aap and Gly contents of the observation group were higher than those of the control group and were positively correlated with ( +θ)/( +β) ratios. Conclusion: ( +θ)/( +β) ratios of quantitative EEG detection of patients with Alzheimer's disease abnormally increase and have good correlation with abnormality of serum inflammatory factors and neuron injury related molecules; it’s an ideal method to evaluate the severity degree ofAlzheimer's disease.