Changes and significance of glucose and insulin cell functions index in Type 2 diabetes patients before and after administration of saxagliptin

摘要

Objective:To investigate the changes and significance of glucose and insulin cell functions index in Type 2 diabetes patients before and after administration of saxagliptin.Methods:A total of 79 cases of patients with type 2 diabetes who treated in our hospital from January 2013 to September 2014 were selected by random sampling method. They were divided into study group (n=40) and control group (n=39) according to the treatment methods. Firstly, the two groups were given metformin treatment, and then the observation group was treated with saxagliptin, while the control group was treated with glimepiride.Results: The FPG, 2hPG, HbA1c levels of after treatment in two groups were significantly lower than the before treatment (P<0.05). The pro-Ins and Pro-Ins/Fins levels after treatment in observation group were significantly lower than control group (P<0.05), while the HOMA-β level was significantly higher than the control group (P<0.05).Conclusion:The administration of saxagliptin can reduce glucose and protect insulin cell function of patients for type 2 diabetes patients.