The pathogenesis mechanism of diabetic cardiomyopathy and alleviation of simvastatin combined benazepril

摘要

Objective:To explore the pathogenesis mechanism of diabetic cardiomyopathy and alleviation of simvastatin combined benazepril.Methods: SD rats were divided into 4 groups: control, diabetic group, SP00125 group and simvastatin combined benazepril group. The cardiac function and serum MDA, SOD, HLD and LDL were detected. The expression of JNK signaling pathway key proteins were analyzed by Western Blotting.Results:The content of HDL and SOD was decreased while MDA and LDL were increased in diabetic group. The expression of JNK and pJNK was also found increased in diabetic group. Simvastatin combined benazepril medication can normalize those abnormalities greatly.Conclusion:Over-activated JNK signaling pathway was involved in diabetic cardiomyopathy and simvastatin combined benazepril exert function by inhibiting JNK pathway.