Rabeprazole's influence on duodenal ulcer patients' serum levels of gastrointestinal peptide hormone and neurotransmitter

摘要

Objective:To observe the effects of rabeprazole of duodenal ulcer, and its influence on the serum levels of gastrointestinal peptide hormone and neurotransmitter.Methods:180 patients with duodenal ulcer were randomly divided into control group and observation group, each group had 90 cases, patients in control group were given routine treatment, and those in observation group were treated with rabeprazole 20 mg/time, 2 times/d, treatment for 4 weeks based on routine treatment. Then gastroscopy and 14C- urea breath test were took before and after treatment for comparison of efficacy between the two groups, and the serum levels of gastrointestinal hormone such as gastrin (Gas), motilin (MTL), somatostatin (SS) and calcitonin gene related peptide (CGRP) and neurotransmitter such as 5- serotonin (5-HT), substance P (SP), nitric oxide (NO), vasoactive intestinal peptide (VIP) of two groups before and after treatment were detected and compared.Results:3, 5 weeks after treatment, the stomach integral of observation group was lower than that of the control group, stomach pain relief time was shorter than control group, Hp eradication rate was higher than control group, and the curative effect of observation group was significantly better than the control group. 3, 5 weeks after treatment, the serum levels of Gas, AM, MTL and 5-HT, SP, NO, VIP level of observation group were significantly lower than that of the control group, while the SS and CGRP were higher than the control group.Conclusion:Rabeprazole can effectively regulate the expression of gastrointestinal peptide hormone and neurotransmitter of patients with duodenal ulcer, shorten the recovery time and improve the curative effect.