首页>
外文期刊>海南医科大学学报(英文版)
>Effect of valsartan combined with beraprost sodium on renal function, blood coagulation function and endothelial injury in patients with hypertension and early renal damage
【24h】
Effect of valsartan combined with beraprost sodium on renal function, blood coagulation function and endothelial injury in patients with hypertension and early renal damage
Objective:To analyze the effect of valsartan combined with beraprost sodium on renal function, blood coagulation function and endothelial injury in patients with hypertension and early renal damage.Method:A total of 200 patients with hypertension and early renal damage were divided into observation group (n=97) (received valsartan combined with beraprost sodium therapy) and control group (n=103) (received valsartan therapy alone) according to different treatment methods. Differences in renal function, blood coagulation function and endothelial injury index levels were compared between the two groups after treatment. Results: Eight weeks after treatment, CysC,β2-MG, Fib, D-D, MPV contents in plasma and UACR,α1-MG, NAG contents in urine of observation group were significantly lower than those of control group, ATIII contents in plasma were significantly higher than that of control group; lower limb artery Vmax value of observation group was significantly higher than those of control group, carotid artery IMT value lower limb artery RI, FMD and NMD value were significantly lower than those of control group.Conclusions: Valsartan combined with beraprost sodium can protect the renal function and avoid further disease progression in patients with hypertension and early renal damage, and it is an ideal solution to disease treatment.
展开▼
机译:目的:分析缬沙坦联合Beraprost钠对高血压和早期肾损伤患者肾功能,血液凝固功能和内皮损伤的影响。方法:共有200例高血压和早期肾损伤分为观察组( n = 97)(接受缬沙坦联合Beraprost钠治疗)和对照组(N = 103)(仅根据不同的处理方法(单独接受缬沙坦治疗)。在治疗后两组比较肾功能,血液凝固功能和内皮损伤指数水平的差异。结果:治疗后八周,血浆和UACR中的CysC,β2-Mg,Fib,DD,MPV含量,α1mg,观察组中的尿液中的NAG内容物显着低于对照组,血浆中的ATIII含量显着显着高于对照组;观察组的下肢动脉Vmax值明显高于对照组,颈动脉IMT值下肢动脉RI,FMD和NMD值显着低于对照组。结合:Valsartan与Beraprost钠相结合,可以保护肾脏保护肾脏功能并避免高血压和早期肾损伤患者进一步的疾病进展,并且是疾病治疗的理想解决方案。
展开▼