Melanoma is a kind of invasive skin cancer, and can progress rapidly, with limited drug therapeutic effect. In recent years, it is found that some MicroRNA plays a vital role in the development of melanoma. From the role of MicroRNA in the malignant transformation and metastasis of melanoma, the research progress is clarified as the following: (1) miR-137, miR-182, and miR-211 can targetedly express MITF, and inhibit the proliferation and invasion of melanoma; (2) miR-221 can promote the deterioration of melanocytes through down regulating c-kit receptor signal pathway; (3) Let-7, miR-143, miR-34, miR-211, miR-210, miR-205 can inhibit the infiltration and migration of melanoma through regulating integrin, MMP, and other target proteins. Conclusions: In consideration of the space-time speciality and biological function diversity in the gene expression, the potential of miRNA as the new target of tumor treatment by the traditional Chinese medicine can not be underestimated.
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