Relationship of serum RBP, NEFA and FKN content with urinary protein excretion and glomerular filtration function damage in patients with early diabetic nephropathy

摘要

Objective:To analyze the relationship of serum RBP, NEFA and FKN content with urinary protein excretion and glomerular filtration function damage in patients with early diabetic nephropathy.Methods: A total of 76 patients with early diabetic nephropathy were included in observation group and 80 healthy subjects were included in control group. Differences in retinol-binding protein (RBP), non-esterified fatty acid (NEFA) and chemokine Fractalkine (FKN) content in serum as well as urinary protein excretion indexes and glomerular filtration function indexes were compared between the two groups immediately after admission, and the correlation of RBP, NEFA and FKN content with the disease was further analyzed.Results:Serum RBP, NEFA and FKN content of observation group were higher than those of control group; 24 h total urine volume, 24 h urinary albumin and urinary albumin excretion rate as well as urine-specific proteins Kim-1, NGAL, L-FABP and CysC content of observation group were higher than those of control group and positively correlated with serum RBP, NEFA and FKN content; GFR level of observation group was lower than that of control group and negatively correlated with serum RBP, NEFA and FKN content while serum Cr, BUN, VF, LP-a,β2-MG and HA content were higher than those of control group and positively correlated with serum RBP, NEFA and FKN content.Conclusions:Serum RBP, NEFA and FKN content significantly increase in patients with early diabetic nephropathy and are correlated with urinary protein excretion and glomerular filtration function damage.