Effect of batroxobin combined with ginkgo dipyidamolum on hearing and hemorheology in patients with sudden hearing loss

摘要

Objective:To explore the effect of batroxobin in combined with ginkgo dipyidamolum on the hearing and hemorheology in patients with sudden hearing loss (SHL).Methods:A total of 80 patients with SHL who were admitted in our hospital from January, 2015 to December, 2015 in ENT Department were included in the study and randomized into the observation group and the control group. The patients in the two groups were given batroxobin injection (10 BU) + 0.9% NaCl (100 mL), ivdrip, once every other day. On this basis, the patients in the observation group were given additional ginkgo dipyidamolum injection (30 mL) + 5% glucose (250 mL), iv drip, 1 time/d. The fasting elbow venous blood before treatment and 10 d after treatment in the two groups was collected. The blood rheometer was used to detect the plasma PV, HS, MS, and LS. The full automatic coagulation apparatus was used to detect TT, PT, ATPP, FIB, and PF. ELISA was used to detect the serum Connexin26 and Connexin30 levels. AC40 audio tester was used to measure the hearing threshold value before and after treatment.Results:PV, HS, MS, and LS levels after treatment in the two groups were significantly reduced when compared with before treatment (P<0.05), and the improved degree of the above indicators in the observation group was significantly superior to that in the control group (P<0.05). TT, PT, and ATPP after treatment in the two groups were significantly elevated, while FIB and PF were significantly reduced when compared with before treatment (P<0.05), and the improved degree of the above indicators in the observation group was significantly superior to that in the control group (P<0.05). Connexin26 and Connexin30 levels after treatment in the two groups were significantly elevated when compared with before treatment (P<0.05). Connexin26 and Connexin30 levels after treatment in the observation group were significantly higher than those in the control group (P<0.05). The hearing threshold value after treatment in the observation group was significantly higher than that in the control group (P<0.05).Conclusions:Batroxobin in combined with ginkgo dipyidamolum can effectively improve the blood hypercoagulation status in SHL patients, up regulate Connexin26 and Connexin30 levels, and improve the hearing, with an accurate efficacy.