Effect of ossotide injection on the bone metabolism and bone mineral density in patients with femoral intertrochanteric fracture

摘要

Objective:To explore the effect of ossotide injection on the bone metabolism and bone mineral density (BMD) in patients with femoral intertrochanteric fracture.Methods:A total of 80 elderly patients with femoral intertrochanteric fracture who were admitted in our hospital from May, 2015 to May, 2016 for PFNA internal fixation were included in the study, served as the fracture group, and randomized into the observation group and the control group with 40 cases in each group. Moreover, 40 healthy individuals who came for physical examinations were served as the healthy group. The fracture patients were performed with PFNA internal fixation of closed reduction under epidural or general anesthesia, and were given anti-infection, anti-coagulation, and functional exercise after operation. On this basis, the patients in the observation group were given ossotide injection (20 mL) + normal saline (250 mL), ivdrip, 1 time/d, for 4 weeks. The morning fasting venous blood before and after treatment in the fracture group and the day in the healthy group was extracted. The full automatic electrochemiluminescence immunity analyzer was used to detect CTX, PINP, and BGP. The full automatic biochemical analyzer was used to detect Ca and P. Colorimetry was used to detect the serum AKP. X-ray bone density apparatus was used to detect BMD.Results: The serum PINP and CTX levels in the fracture group were significantly higher than those in the healthy group, while BGP level was significantly lower than that in the healthy group. The serum PINP and CTX levels after treatment in the two groups were significantly reduced when compared with before treatment, while BGP level was significantly elevated, and those in the observation group were significantly superior to those in the control group. After treatment, Ca, P, AKP, and BMD in the control group were not significantly different from those before treatment, Ca, P, and BMD in the observation group were significantly elevated, while AKP was significantly reduced, significantly superior to those in the control group.Conclusions:Ossotide injection can preferably regulate the serum bone metabolism in patients with femoral intertrochanteric fracture, increase BMD, improve the functional status, and effectively promote the fracture healing.