Observation on the influence of ulinastatin for the cerebral protection and inflammatory reaction of patients with craniocerebral injury surgery during the perioperative period

摘要

Objective:To observe the influence situation of ulinastatin for the cerebral protection and inflammatory reaction of patients with craniocerebral injury surgery during the perioperative period, in order to understand the application value of ulinastatin in the patients with craniocerebral injury surgery.Methods:A total of 54 patients with craniocerebral injury surgery in our hospital from July 2014 to May 2015 were selected as the study object, and 54 patients were randomly divided into two groups, 27 patients in control group were treated with conventional perioperative treatment, 27 patients in observation group were treated with ulinastatin on the conventional perioperative treatment, then the cerebral blood flow parameters, serum nerve function related indexes, pro-inflammatory cytokines and anti-inflammatory cytokines of two groups before the treatment and at 1st, 3rd and 5th day after the treatment were analyzed and compared.Results:The cerebral blood flow parameters, serum nerve function related indexes, pro-inflammatory cytokines and anti-inflammatory cytokines of two groups before the treatment were compared, while those statistical indexes of observation group at 1st, 3rd and 5th day after the treatment were all better than those of control group, the differences were all significant.Conclusion:The influence role of ulinastatin for the cerebral protection and inflammatory reaction of patients with craniocerebral injury surgery during the perioperative period is better, and its application value for the patients with craniocerebral injury surgery is relatively higher.