Effect of atorvastatin combined with Tongxinluo on hemorheology and inflammatory factors in patients with coronary heart disease

摘要

Objective:To analyze the effect of atorvastatin combined with Tongxinluo on hemorheology and inflammatory factors in patients with coronary heart disease.Methods: A total of 42 patients with coronary heart disease treated in our hospital between December 2012 and December 2015 were selected and randomly divided into observation group and control group (n=21), control group received routine therapy, observation group received routine therapy + atorvastatin combined with Tongxinluo therapy, and then cardiac function, blood viscosity as well as serum lipid metabolism indexes and inflammation indexes were compared between the two groups after treatment.Results:After 3 courses of treatment, EF value and E/A ratio of observation group were significantly higher than those of control group, and whole blood high shear viscosity, whole blood low shear viscosity and plasma viscosity were significantly lower than those of control group; serum TC, TG, LDL-C, Leptin, Resistin, Visfatin, IL-18, TNF-C, sTREM-1 and MMP-9 levels of observation group after treatment were significantly lower than those of control group, and IL-4, IL-10, IL-37 and MFG-E8 levels were significantly higher than those of control group.Conclusion:Atorvastatin combined with Tongxinluo can optimize the state of coronary heart disease, and it plays a positive role in optimizing hemorheology, inflammation and other aspects.