Effect of preemptive analgesia with parecoxib sodium on inflammatory cytokine and stress in puerpera after cesarean section

摘要

Objective:To explore the effect of preemptive analgesia (PA) with parecoxib sodium on the inflammatory cytokine and stress in puerpera after cesarean section.Methods:A total of 70 pregnant women who were admitted in our hospital from May, 2015 to May, 2016 for cesarean section were included in the study and randomized into the observation group and the control group with 35 cases in each group. A venous channel was established. The heart rate, blood pressure, and oxygen saturation were continuously monitored by the monitor. The patients in the observation group were intravenously injected with parecoxib sodium (40 mg) and normal saline (2 mL), while the patients in the control group were intravenously injected with normal saline (2 mL) 30 min before anesthesia induction. The venous blood when entering the operation room, after operation, 4 h, 8 h, and 12 h after operation was extracted. The plasma IL-6, TNF-α, P substance, E, and NE levels were detected.Results: IL-6 and TNF-αlevels after operation in the two groups were elevated, reached the peak 4 h after operation, and were gradually reduced 8 h after operation. IL-6 and TNF-αα levels at each timing point after operation in the observation group were significantly lower than those in the control group (P<0.05). P substance after operation in the two groups was elevated, reached the peak 4 h after operation, and was gradually reduced 8 h after operation. P substance level at each timing point after operation in the observation group was significantly lower than that in the control group (P<0.05). N and NE levels after operation in the two groups were elevated, reached the peak 4 h after operation, and were reduced to the levels when entering the operation time 12 h after operation. N and NE levels at each timing point after operation in the observation group were significantly lower than those in the control group (P<0.05).Conclusions:PA with parecoxib sodium in application of puerpera after cesarean section can effectively reduce the stress reaction, decrease the production of inflammatory cytokines, with a favorable analgesic effect, and further reduce the occurrence of postoperative complications.