Effect of compound glycyrrhizin combined with NB-UVB on T lymphocyte subsets and related cytokines in patients with psoriasis vulgaris

摘要

Objective:To explore the effect of compound glycyrrhizin in combined with narrow band ultraviolet B (NB-UVB) on T lymphocyte subsets and related cytokines in patients with psoriasis vulgaris.Methods:A total of 70 patients with psoriasis vulgaris who were admitted in our hospital from March, 2015 to March, 2016 were included in the study and randomized into the study group and the control group. The patients in the control group were given NB-UVB for whole body irradiation, with an initial dose of 0.3 J/cm2, 0.2-0.3 J/cm2 increased every time, 3 times a week. On this basis, the patients in the study group were intravenously injected with compound glycyrrhizin (80 mg) + 5% glucose (250 mL), 1 time a day. Four-week treatment was regarded as one course. ELISA was used to detect the serum IL-17 and IL-22 levels. FCM was used to detect the levels of peripheral blood T lymphocytes (CD4+, CD8+, CD4+/CD8+). PASI score before and after treatment was evaluated.Results:The levels of IL-17 and IL-22 after treatment in the two groups were significantly reduced when compared with before treatment (P<0.05), and the reduced degree in the study group was significantly superior to that in the control group (P<0.05). The levels of CD4+ and CD4+/CD8+ after treatment in the two groups were significantly elevated, but CD8+ was significantly reduced when compared with before treatment (P<0.05), and those in the study group were significantly superior to those in the control group (P<0.05). PASI score after treatment in the two groups was significantly reduced when compared with before treatment (P<0.05), and the reduced degree in the study group was significantly superior to that in the control group (P<0.05). Conclusions: Compound glycyrrhizin in combined with NB-UVB in the treatment of psoriasis vulgaris can effectively down regulate the cytokine level, recover T cell immune function, and improve PASI score; therefore, it deserves to be widely recommended in the clinic.