Effect of azithromycin, terbutaline combined with montelukast on airway function and gradient of infection in cough variant asthma children with infection

摘要

Objective:To analyze the effect of azithromycin, terbutaline combined with montelukast on airway function and gradient of infection in cough variant asthma children with infection. Methods: A total of 116 cases of cough variant asthma children with infection were included in the study and randomly divided into observation group and control group (n=58), control group received azithromycin treatment, observation group received azithromycin, terbutaline combined with montelukast treatment, and then differences in basic lung function and small airway function, asthma attack and airway remodeling-related indicators, infection-related indicators, etc. were compared between two groups after treatment.Results: Basic lung function indexes FEV1 and FVC of observation group after treatment were significantly higher than those of control group, and small airway function indexes MMEF, FEF50% and FEF75% were significantly lower than those of control group; serum ECP, IgE, IL-5, MMP-2, MMP-9, TIMP-1, PET, CRP and IL-4 levels of observation group after treatment were lower than those of control group while IFN-γ and hBD-1 levels were higher than those of control group.Conclusion:Azithromycin, terbutaline combined with montelukast can improve airway function and infection status and promote disease rehabilitation in cough variant asthma children with infection.