Relationship of serum CCL20 and PCDGF levels with recurrence of non-small cell lung cancer after thoracoscopic radical operation

摘要

Objective:To study the relationship of serum CCL20 and PCDGF levels with recurrence of non-small cell lung cancer after thoracoscopic radical operation.Method: A total of 93 patients with non-small cell lung cancer who received thoracoscopic radical operation in our hospital were selected, followed up for 2 years and divided into recurrence group and non-recurrence group, serum was collected before operation as well as 30 d and 90 d after operation to determine CCL20 and PCDGF levels, chest CT perfusion imaging was carried out after recurrence and the perfusion parameters were measured, and recurrent tumor tissue was collected to determine apoptosis molecule levels.Results: Before operation as well as 30 d and 90 d after operation, serum CCL20 and PCDGF levels of recurrence group and non-recurrence group were not significantly different; 180 d after operation, serum CCL20 and PCDGF levels of recurrence group were significantly higher than those of non-recurrence group, and there were significant differences between two groups. Patients with recurrence were grouped according to serum CCL20 and PCDGF levels 180 d after operation, BF, BV and PS of recurrent patients with high CCL20 and PCDGF levels were sig.nificantly higher than those of recurrent patients with low CCL20 and PCDGF levels while MTT and TTP as well as Caspase-3, -8, -9, pULK, Beclin1, PICKC3, Atg21 and Atg24 levels in tumor tissue were lower than those of recurrent patients with low CCL20 and PCDGF levels.Conclusion: Monitoring of postoperative serum CCL20 and PCDGF levels can provide reference for the evaluation of postoperative non-small cell lung cancer recurrence, and serum CCL20 and PCDGF levels 180 d after operation are closely related to tumor tissue perfusion and cell apoptosis.