Effect of Jianpi Bushen decoction on PARC/CCL-18 content, degree of airway remodeling and MAPKs pathway function of stable COPD patients

摘要

Objective:To analyze effect of Jianpi Bushen decoction on PARC/CCL-18 content, degree of airway remodeling and MAPKs pathway function of stable COPD patients.Methods: A total of 90 stable COPD patients received treatment in our hospital from February 2012 to January 2015, and all patients learned about the research process, signed informed consent forms and then were included in the research. Control group received conventional Western medicine treatment, observation group received Jianpi Bushen decoction combined with conventional treatment, and then differences in circulating blood PARC/CCL-18 contents, airway remodeling-related index levels and MAPKs pathway function were compared between two groups.Results:Serum PARC/CCL-18 content of observation group after treatment was lower than that of control group (P<0.05); serum CTGF, b-FGF, TGF-β1, IL-25, Smad3, YKL-39 and Activin A values of observation group after treatment were lower than those of control group (P<0.05); predicated values of FEV1 and MMEF of observation group after treatment were higher than those of control group while T, AI, WA and WA% values were lower than those of control group (P<0.05); the mRNA expression levels of MAPKs pathway downstream molecules ERK, p38 and c-Jun in serum and induced sputum of observation group after treatment were lower than those of control group (P<0.05).Conclusions: Jianpi Bushen decoction treatment of stable COPD patients can effectively inhibit airway remodeling process, promote microenvironment stability while hinder MAPKs pathway function, and it has positive clinical significance.