Effect of sequential therapy of interferon and thymosinα1 on virus replication and liver fibrosis in patients with nucleoside drugs-resistant hepatitis B cirrhosis

摘要

Objective:To analyze the effect of sequential therapy of interferon and thymosin α1 on virus replication and liver fibrosis in patients with nucleoside drugs-resistant hepatitis B cirrhosis. Methods: A total of 86 patients with hepatitis B cirrhosis were the research subjects and divided into observation group and control group (n=43) according to random number table, control group received interferon therapy alone, observation group received sequential therapy of interferon and thymosin α1, and then difference in virus replication, liver fibrosis and other indicators were compared between two groups.Results:HBV-DNA load, serum ALT and AST values as well as HA, LN, C-Ⅳ and PCⅢ values of observation group after the treatment were lower than those of control group (P<0.05); serum TBA and Treg values of observation group after treatment were lower than those of control group, and PAB, CHE, Th17 cell and Th17/Treg ratio were higher than those of control group (P<0.05).Conclusions:Sequential therapy of interferon and thymosin α1 can optimize the overall condition in patients with nucleoside drugs-resistant hepatitis B cirrhosis, inhibit virus replication and slow down the process of liver fibrosis, and it has positive clinical significance.