Clinical application comparison between laparoscopic repair and conventional open repair of perforated gastroduodenal ulcer

摘要

Objective:To analyze the different effects of clinical application of laparoscopic repair and conventional open repair of perforated gastroduodenal ulcer.Methods: A total of 98 patients with gastroduodenal ulcer perforation were included in the study, hospital stay interval was from September 2012 to November 2014, and according to different surgeries they received, patients were divided into laparoscopic group and open surgery group (n=49). Peripheral blood and urine 1 h after operation were obtained from two groups to detect the differences in levels of pain-related indexes, intestinal wall damage-related indexes, Th1 and Th2 type factors and neurotransmitter type indexes.Results: Serum SP, NPY, PGE2 and HA values of laparoscopic group 1 h after operation were lower than those of open surgery group; urine LMR and IFABP of laparoscopic group 1h after operation were lower than those of open surgery group, and serum ET, PG, D-lactate, DAO and sICAM-1 values were lower than those of open surgery group; serum IFN-γ, TNF-α, IL-2, IL-4, IL-6 and IL-10 values of laparoscopic group 1 h after operation were lower than those of open surgery group; serum 5-HTP, 5-HIAA, NE and DA values of laparoscopic group 1 h after operation were lower than those of open surgery group, and Ach level was higher than that open surgery group.Conclusion:On the premise of protecting gastrointestinal function, laparoscopic repair of perforated gastroduodenal ulcer can reduce surgical inflammatory stress trauma in patients, and has positive clinical significance.