Effect of liraglutide and metformin on constitution, metabolism and micro-inflammatory state in newly diagnosed type 2 diabetic mellitus patients with obesity

摘要

Objective:To analyze the effect of liraglutide and metformin on the constitution, metabolism and micro-inflammatory state in newly diagnosed type 2 diabetic mellitus patients with obesity.Methods:A total of 55 cases of newly diagnosed type 2 diabetic mellitus patients with obesity were included for study and divided into observation group (n=30) and control group (n=25) according to different treatment plans. Control group received metformin treatment alone, observation group received liraglutide and metformin treatment, and levels of glucolipid metabolism indicators, body mass index and fibrinolytic activity-related indicators, micro-inflammation-related signaling pathways, illness-related indicators, etc of two groups were detected after one course of treatment.Results:FPG, GHbA1c, TC, TG and LDL-C values in venous blood of observation group after treatment were lower than those of control group;waistline, hipline and waist-hip ratio of observation group decreased after treatment, TM value was lower than that of control group while t-PA value was higher than that of control group; TLR4-NF-κB signaling pathway and DAG/PKC signaling pathway downstream TLR4, p-NF-κB p65, DAG and PKC protein expression levels of observation group after treatment were significantly lower than those of control group; serum APN, Nesfatin-1 and ISI values of observation group after treatment were higher than those of control group while LP, Chemerin, RBP4 and FINS values were lower than those of control group.Conclusions: Combined therapy of liraglutide and metformin can significantly improve the constitution of newly diagnosed type 2 diabetic mellitus patients with obesity, optimize the general condition and be expected to improve treatment outcome.