Effect of mitiglinide combined laser photocoagulation on blood glucose, blood lipid and vascular endothelial function in diabetic retinopathy

摘要

Objective:To observe the effect of mitiglinide combined laser photocoagulation on blood glucose, blood lipid and vascular endothelial function in diabetic retinopathy.Methods:A total of 106 patients with diabetic retinopathy treated in our hospital from January 2014 to January 2015 were selected and assigned into the separate group and combined group. Fifty-three patients in the separate group only received oral mitiginide, while other 53 patients in the combined group received oral mitiglinide and laster photocoagulation surgery. Before and after treatment, the FBG, 2hPBG, HbA1c, TC, TG, HDL-C, LDL-C, ET-1, VEGF, PEDF, ICAM-1, FMD of patients in the two groups were analyzed.Results: After treatment, the blood glucose and blood lipid indexes of patients in the two groups were improved significantly, and there was no statistical difference between the two groups. The ET-1, ICAM-1 and VEGF of patients in the two groups decreased, and the decrease of the combined group was more distinctly. The PEDF and FMD in the two groups all increased, and the combined group changed more obviously. The regression of the blood vessel and the recovery of visual acuity in the combined group were better than the separate group.Conclusions:Mitiglinide combined with laser photocoagulation can effectively improve the level of blood glucose and blood lipid, promote vascular endothelial function and inhibit the formation of retinal neovascularization so as to improve the visual acuity level.