The study of the effect of adefovir on the liver function and fibrosis state for patients with hepatitis B cirrhosis

摘要

Objective:To explore the effect of adefovir on liver function and fibrosis index, HBV-DNA, portal vein diameter and the thickness of spleen for patients with hepatitis B cirrhosis. Methods: A total of 102 cases of hepatitis Bcirrhosisin thedepartment of our hospital from April 2013 to November 2015 were chosen. According to the admission of the order number, the odd number was as the control group, and the even number was as the observation group, 51 cases in each group. The two groups of patients were given with conventional liver treatment, on the basis of the treatment, the control group was treated with lamivudine, the observation group was taken with oral adefovir dipivoxil tablets therapy, and the treatment period was six months. The changes of liver function, liver fibrosis, serum HBV-DNA level, portal vein diameter, thickness variation spleen for the two groups before and after treatment were taken for statistical analysis.Results: The alanine aminotransferase (ALT) and total bilirubin (TBIL), serum albumin (ALB), prothrombin activity (PTA) of liver function before treatment were without significant differences. The hepatic fibrosis hyaluronidase (HA), laminin (LN),Type IV collagen (IV-C) and type III procollagen (PCIII) were compared, there were no statistical differences; serum HBV-DNA and portal vein diameter, thickness of spleen had no significant difference. Compared after treatment, the ALT and TBIL in the observation group were significantly decreased compared with the control group, ALB, PTA were significantly increased, the differences were significant. The HA, LN, IV-C of fibrosis markers and PCIII in the observation group were lower compared with control group, the differences were with statistical significance. The serum HBV-DNA negative rate in the observation group was significantly higher than the control group, there were significant differences. The portal vein diameter, thickness of spleen in the observation group after treatment were lower than the control group, and the differences were significant.Conclusions: The application of adefovir on the liver function and fibrosis state for patients with hepatitis B cirrhosis can further improve the liver function, significantly reduce the hepatic fibrosis state of the patient, reduce portal vein diameter and thickness of spleen, improve patients’ HBV DNA negative rate, thus delay the process of development of cirrhosis, and the clinical treatment is better.