Effect of atorvastatin in combined with Naoxintong capsue on carotid atherosclerosis in patients with cerebral infarction

摘要

Objective:To explore the clinical efficacy of atorvastatin in combined with Naoxintong capsue in the treatment of carotid atherosclerosis (CAS) in patients with cerebral infarction.Methods:A total of 120 patients with cerebral infarction merged with CAS who were admitted in our hospital from February, 2015 to February, 2016 were included in the study and randomized into the observation group and the control group. The patients in the control group were given bayaspirin, 100mg/time, before sleep, and atorvastatin, 20 mg/time, at dinner. On this basis, the patients in the observation group were given Buchang Naoxintong capuse, 4 capusles/time, 3 times/d. Six-month treatment was regarded as one course. The full automatic biochemical analyzer was used to the serum TC, TG, HDL-C, and LDL-C levels. The immunoturbidimetric assay was used to detect the serum CRP level. The color Doppler ultrasonic diagnosis apparatus was used to detect IMT and the plaque area.Results: After 6-month treatment, the levels of TC, TG, and LDL-C in the two groups were significantly reduced, while HDL-C was significantly elevated when compared with before treatment (P<0.05). The improvement of various indicators in the observation was significantly superior to that in the control group (P<0.05). After 6-month treatment, CRP level in the two groups was significantly reduced when compared with before treatment (P<0.05), and the reduced degree in the observation group was significantly superior to that in the control group (P<0.05). After 6-month treatment, IMT and the plaque area in the two groups were significantly reduced when compared with before treatment (P<0.05), and the reduced degree in the observation group was significantly superior to that in the control group (P<0.05).Conclusions:The combined application of atorvastatin and Naoxintong capsule in the treatment of CAS in patients with cerebral infarction can effectively regulate the serum lipid level, reduce the inflammatory reaction, improve the atherosclerotic symptoms, and reduce the occurrence and recurrence of cerebral infarction; therefore, it deserves to be widely recommended in the clinic.