Effect of Jiedu Lifeitang on T lymphocyte subsets and inflammatory factors in patients with viral pneumonia

摘要

Objective:To observe the effect of Jiedu Lifeitang on T lymphocyte subsets and inflammatory factors in adults with viral pneumonia.Methods: A total of 104 cases with viral pneumonia randomly included in the study were divided into treatment group (54 cases) and control group (50 cases). The control group was given ribavirin based on oral medical, and the treatment group was given the Jiedu Lifeitang based on the control group. After treatment for 1 week, the changes of T lymphocyte subsets (CD3+,CD4+,CD8+,CD4+/CD8+) and inflammatory factors (IL-6, IL-8, CRP, TNF-α) between the two groups were observed.Results:Before treatment, the difference of CD3+, CD4+, CD8+ and CD4+/CD8+ in both groups was not statistically significant (P>0.05). After treatment, the levels of CD3+, CD4+, CD4+/CD8+ significantly increased and CD8+ significantly decreased in both groups (P<0.05), the levels of IL-6, IL-8, CRP, TNF-α significantly decreased in both groups (P<0.05). The levels of CD3+, CD4+ and CD4+/CD8+ in treatment group were (66.47±21.24)%, (36.74±12.05)% and (1.77±0.31), respectively, which were significantly higher than that in the control group after treatment, the levels of CD8+, IL-6, IL-8,CRP and TNF-α in treatment group were (20.09±8.08)%, (20.75±10.23) ng/mL, (8.37±4.45) ng/mL, (3.67±1.48) mg/L and (22.12±9.14) ng/L, respectively, which were significantly lower than that in the control group after treatment (P<0.05).Conclusions: Jiedu Lifeitang can regulate immune function and inhibit inflammatory reaction in adults with viral pneumonia.