Applied research of the combination of indocyanine green and methylene blue in mapping sentinel lymph nodes for breast cancer patients

摘要

Objective:To discuss the application value of combination of indocyanine green and methylene blue in sentinel lymph node biopsy for patients with breast cancer. Methods:A total of 200 cases of breast cancer patients were selected and randomly divided into test group and control group, each of 100 cases. The test group received indocyanine green and methylene blue as the lymphatic mapping tracers and the control group received methylene blue only. Intraoperative frozen section was performed, followed by conventional histopathology. Results:Thepositive rate, sensitivity, false negative rate, consistent rate and the Kappa values of the test group were 98%(98/100), 95.74%(45/47), 4.26%(2/47), 96.94%%(95/98) and 0.860, and 94%(94/100) and 86.96%(40/46), 13.04%(6/46), 93.62%(88/94) and 0.758 of control group;There were statistical significance between the differences of the positive rate, sensitivity, false negative rate, consistent rate and the Kappa values of test group and control group. Conclusion:Combination of indocyanine green and methylene blue for mapping sentinel lymph nodes in breast cancer patients has the advantages of real-time visual and accurate positioning and can reduce the false negative rate, to provide the important evidence based medicine foundation for the surgical treatment of breast cancer.