Effect of alprostadil on hemorheology, immune function, MDA, SOD and ROS in patients with diabetic nephropathy

摘要

Objective: To investigate the effect of alprostadil on hemorheology, oxidative stress and immune function in patients with diabetic nephropathy. Methods:A total of 90 cases of diabetic nephropathy patients were divided into control group (45 cases) and observation group (45 cases). The control group was treated by conventional therapy, and the observation group was received extra alprostadil. The levels of hemorheology, oxidative stress and immune function indexes were measured and compared. Results:The levels of blood glucose, blood lipid and UAER had a significant improvement in both groups, and the level of UAER in the observation group decreased more significantly than that in the control group after treatment;the levels of hemorheology indexes (high, middle and low shear of blood viscosity, plasma viscosity, deformation index and erythrocyte aggregation index) had a significant improvement after treatment, and the levels of low shear of blood viscosity and erythrocyte aggregation index in the observation group decreased more significantly than that in the control group after treatment. The levels of oxidative stress indexes (MDA, ROS and SOD) had a significant improvement in both groups, and the levels of MDA, ROS and SOD decreased more significantly after treatment. The levels of CD4+, CD4+/CD8+ in the observation group increased significantly after treatment, while the level of CD8+ had no significant improvement. The levels of CD4+, CD8+,CD4+/CD8+in the control group had no significant differences, while the levels of CD4+, CD4+/CD8+in the observation group were significantly higher than that in the control group. Conclusions:Alprostadil treatment can obviously improve renal function, hemorheology, oxidative stress and immune function in patients with diabetic nephropathy.