Researches on the diagnosis value of tumor markers combined detection to middle-aged patients with pulmonary tuberculosis complicating lung cancer

摘要

Objective: To discuss the diagnosis value of six kinds of tumor markers (CEA, NSE, CYFRA21-1, CA125, CA199, AFP) combined detection to middle-aged patients with pulmonary tuberculosis complicating lung cancer. Methods: A total of 52 cases with pulmonary tuberculosis complicating lung cancer who were admitted in our hospital between January 2014 and April 2015 were selected as A Group and 76 cases with pulmonary tuberculosis were selected as B Group, and 118 cases with physical examination during the corresponding period were selected as C Group. Tumor markers (CEA, NSE, CYFRA21-1, CA125, CA199 and AFP) levels of patients in each group were detected. Results:CEA, NSE, CYFRA21-1, CA125, CA199 and AFP levels of patients in A Group were (17.56±8.38) g/L, (40.12±5.22) ng/mL, (7.32±2.41) g/L, (53.27±10.26) U/mL, (41.26±9.41) U/mL and (24.17±9.46) ng/ml respectively, which was significantly higher than that in B Group and C Group, and difference had statistical significance;comparative difference of tumor markers levels between B Group and C Group had no statistical significance;CEA and CYFRA21-1 levels of patients with small cell lung cancer in A Group were (26.32±9.16) g/L and (11.47±2.18) g/L respectively, which was significantly higher than those patients with non-small cell lung cancer, but NSE level was (15.17±5.91) ng/mL, which was lower than those patients with non-small cell lung cancer;comparative difference of CA125, CA199 and AFP levels between small cell lung cancer patients and non-small cell lung cancer patients had no statistical significance;sensitivity of CEA was the highest (50.00%), specificity of CA199 was the highest(91.24%). Sensitivity of 6 kinds of tumor markers combined detection was 71.15%, and specificity was 89.69%. Conclusion:CEA, NSE, CYFRA21-1, CA125, CA199 and AFP combined detection had a certain clinical value for the diagnosis of pulmonary tuberculosis complicating lung cancer .