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《海南医科大学学报(英文版)》
>Expression of transcription factors Twist and Snail in cervical intraepithelial neoplasia tissues and their relationship with epithelial-mesenchymal transition and cell proliferation
Expression of transcription factors Twist and Snail in cervical intraepithelial neoplasia tissues and their relationship with epithelial-mesenchymal transition and cell proliferation
Objective:To study the expression of transcription factors Twist and Snail in cervical intraepithelial neoplasia tissues and their relationship with epithelial-mesenchymal transition and cell proliferation.Methods: cervical intraepithelial neoplasia tissues (n=67) and normal cervical tissues (n=85) were collected, and the contents of Twist and Snail as well as epithelial-mesenchymal transition-related molecules and proliferation-related molecules in the tissues were detected.Results:Twist and Snail contents in CIN cervical tissues were lower than those in normal cervical tissues; Twist, Snail, PI3K, Akt, STAT3, Vimentin, N-cadherin, Prdx4, EZH2 and STOML-2 contents in CIN cervical tissues were higher than those in normal cervical tissues, and E-cadherin content was significantly lower than that in normal cervical tissues; E-cadherin content in CIN tissues with high expression of Twist and Snail was significantly lower than that in CIN tissues with low expression of Twist and Snail, and Vimentin, N-cadherin, Prdx4, EZH2 and STOML-2 contents were higher than those in CIN tissues with low expression of Twist and Snail.Conclusions:Transcription factors Twist and Snail expression increase and downstream signaling pathway function is enhanced in cervical intraepithelial neoplasia tissues; Twist and Snail can regulate epithelial-mesenchymal transition and cell proliferation.
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